Welcome to another general discussion thread! Feel free to use this thread to talk about things you have watched recently, questions you have, or recommendations you want to give!
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I will second the Apocalypse Hotel recommendation others have offered.
Mushishi is pretty much my favorite anime ever, so I have often tried to chase that same high. Here are two that I think scratch similar itches, but are a bit different:
Kino’s Journey - This is an anthology series like Mushishi where the titular Kino goes around exploring a new city-state each episode with their own rules/culture/etc. The series can get pretty dark (like Mushishi), and happy endings are not guaranteed. This is probably my top recommendation that is the closest to Mushishi. There are two series adapting these novels. I recommend starting with the 2017 series and then watching the 2003 version only if you are really into it. Some of the episodes adapt the same part of the novels, but many are different.
Natsume’s Book of Friends - This is mostly an anthology series, but there are elements that act as story throughlines. Basically, Natsume is a student that is able to see and interact with the yokai that are all through the world, but most people can’t see (this show’s version of mushi). This ability is something that he inherited from his grandmother, along with a powerful book containing the names of yokai that she met in her lifetime. He then goes around trying to return the names of the yokai that his grandmother took and learn more about her and his own past in the process.